Circular proteins--no end in sight.

  title={Circular proteins--no end in sight.},
  author={Manuela Trabi and David J. Craik},
  journal={Trends in biochemical sciences},
  volume={27 3},
Circular proteins are a recently discovered phenomenon. They presumably evolved to confer advantages over ancestral linear proteins while maintaining the intrinsic biological functions of those proteins. In general, these advantages include a reduced sensitivity to proteolytic cleavage and enhanced stability. In one remarkable family of circular proteins, the cyclotides, the cyclic backbone is additionally braced by a knotted arrangement of disulfide bonds that confers additional stability and… CONTINUE READING
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