Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids.

@article{Zsila2004CircularDS,
  title={Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids.},
  author={Ferenc Zsila and Zsolt Bik{\'a}di and Mikl{\'o}s Simonyi},
  journal={Organic & biomolecular chemistry},
  year={2004},
  volume={2 20},
  pages={2902-10}
}
For the first time, an interaction between the non-toxic, cancer chemopreventive agent curcumin and both natural and synthetic DNA duplexes has been demonstrated by using circular dichroism (CD) and absorption spectroscopy techniques. Upon addition of curcumin to calf thymus DNA, poly(dG-dC).poly(dG-dC) and poly(dA-dT).poly(dA-dT) solutions, an intense positive induced CD band centered around 460-470 nm was observed depending on the actual pH and Na+ ion concentration of the medium; no CD… CONTINUE READING

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