Circular dichroism of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and various derivatives.

Abstract

We have recorded the near- and far-ultraviolet circular dichroism spectra of diphtheria toxin, Pseudomonas aeruginosa exotoxin A, and derivatives of these toxins. The far-ultraviolet spectra of various forms of diphtheria toxin were virtually identical, implying that no major changes in secondary structure accompany proteolytic nicking or dimerization of… (More)

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