Circular dichroism and its application to the study of biomolecules.

  title={Circular dichroism and its application to the study of biomolecules.},
  author={Stephen R. Martin and Maria J. Schilstra},
  journal={Methods in cell biology},
Circular dichroism (CD) is an excellent method for the study of the conformations adopted by proteins and nucleic acids in solution. Although not able to provide the beautifully detailed residue-specific information available from nuclearmagnetic resonance (NMR) and X-ray crystallography, CD measurements have two major advantages: they can be made on small amounts of material in physiological buffers and they provide one of the best methods for monitoring any structural alterations that might… CONTINUE READING