Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions

@article{Zhao2006CircularCC,
  title={Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions},
  author={Zhihu Zhao and Gholamreza Tavoosidana and Mikael Sj{\"o}linder and Anita G{\"o}nd{\"o}r and Piero Mariano and Shuangshuang Wang and Chandrasekhar Kanduri and M. Y. Lezcano and Kuljeet Singh Sandhu and Umashankar Singh and Vinod Pant and Vijay Tiwari and Sreenivasulu Kurukuti and Rolf Ohlsson},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={1341-1347}
}
Accumulating evidence converges on the possibility that chromosomes interact with each other to regulate transcription in trans. To systematically explore the epigenetic dimension of such interactions, we devised a strategy termed circular chromosome conformation capture (4C). This approach involves a circularization step that enables high-throughput screening of physical interactions between chromosomes without a preconceived idea of the interacting partners. Here we identify 114 unique… CONTINUE READING

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