Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.

@article{Chen2017CircularRP,
  title={Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.},
  author={Jie Chen and Yan Li and Qiupeng Zheng and Chunyang Bao and Jian He and Bingguang Chen and Dongbin Lyu and Biqiang Zheng and Yu Xu and Ziwen Long and Ye Zhou and Huiyan Zhu and Yanong Wang and Xianghuo He and Ying-qiang Shi and Shenglin Huang},
  journal={Cancer letters},
  year={2017},
  volume={388},
  pages={208-219}
}
Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The… CONTINUE READING