Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues.

@article{Filippenkov2015CircularRO,
  title={Circular RNA of the human sphingomyelin synthase 1 gene: Multiple splice variants, evolutionary conservatism and expression in different tissues.},
  author={I. B. Filippenkov Filippenkov and Olga Yu Sudarkina and Svetlana A Limborska and Lyudmila V Dergunova},
  journal={RNA biology},
  year={2015},
  volume={12 9},
  pages={
          1030-42
        }
}
The human sphingomyelin synthase 1 gene (SGMS1) encodes an essential enzyme that is involved in the synthesis of sphingomyelin and diacylglycerol from phosphatidylcholine and ceramide. Among the products of SGMS1, we found new transcripts, circular RNAs (circRNAs), that contain sequences of the gene's 5' untranslated region (5'UTR). Some of them include the gene's coding region and fragments of introns. An analysis of the abundance of circRNAs in human tissues showed that the largest… CONTINUE READING
1
Twitter Mention