Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.

@article{Zhong2017CircularRM,
  title={Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.},
  author={Zhenyu Zhong and Mengge Huang and Mengxin Lv and Yunfeng He and Changzhu Duan and Luyu Zhang and Jun-xia Chen},
  journal={Cancer letters},
  year={2017},
  volume={403},
  pages={305-317}
}
Accumulating evidences indicate that circular RNAs (circRNAs) play a vital role in modulating gene expression. However, the mechanisms underlying circRNAs remain largely elusive. Here, we screened circRNA and mRNA expression profiles of bladder carcinoma (BC) using microarray analysis. We found that circRNA-MYLK and VEGFA were significantly up-regulated and co-expressed in BC. Importantly, circRNA-MYLK levels were related to the progression of stage and grade of BC. Mechanistically, we… CONTINUE READING