Circular RNA: an emerging key player in RNA world

  title={Circular RNA: an emerging key player in RNA world},
  author={Xianwen Meng and Xue Li and Peijing Zhang and Jingjing Wang and Yincong Zhou and Ming Chen},
  journal={Briefings in bioinformatics},
  volume={18 4},
Insights into the circular RNA (circRNA) exploration have revealed that they are abundant in eukaryotic transcriptomes. Diverse genomic regions can generate different types of RNA circles, implying their diversity. Covalently closed loop structures elevate the stability of this new type of noncoding RNA. High-throughput sequencing analyses suggest that circRNAs exhibit tissue- and developmental-specific expression, indicating that they may play crucial roles in multiple cellular processes… CONTINUE READING
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Detecting and characterizing circular RNAs

Nature Biotechnology • 2014
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