Circular Permutations in the Molecular Evolution of DNA Methyltransferases

  title={Circular Permutations in the Molecular Evolution of DNA Methyltransferases},
  author={Albert Jeltsch},
  journal={Journal of Molecular Evolution},
  • A. Jeltsch
  • Published 1 July 1999
  • Biology
  • Journal of Molecular Evolution
Abstract. Circular permutations of genes during molecular evolution often are regarded as elusive, although a simple model can explain these rearrangements. The model assumes that first a gene duplication of the precursor gene occurs in such a way that both genes become fused in frame, leading to a tandem protein. After generation of a new start codon within the 5′ part of the tandem gene and a stop at an equivalent position in the 3′ part of the gene, a protein is encoded that represents a… 
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