Circuitry linking opioid-sensitive nociceptive modulatory systems in periaqueductal gray and spinal cord with rostral ventromedial medulla

@article{Morgan1992CircuitryLO,
  title={Circuitry linking opioid-sensitive nociceptive modulatory systems in periaqueductal gray and spinal cord with rostral ventromedial medulla},
  author={Michael M. Morgan and Mary Magdalen Heinricher and Howard L Fields},
  journal={Neuroscience},
  year={1992},
  volume={47},
  pages={863-871}
}
The interactions among opioid-sensitive nociceptive modulatory systems, which include the midbrain periaqueductal gray, rostral ventromedial medulla and spinal cord, are likely to play a central role in the potent antinociception that results when morphine is administered systemically. The aim of the present study was to investigate the mechanisms through which local application of morphine, either in the periaqueductal gray or at the lumbar spinal cord in the rat, influences the activity of… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Biological sciences related to headache.

Handbook of clinical neurology • 2010
View 4 Excerpts
Highly Influenced

Lesions of the periaqueductal gray and rostral ventromedial medulla disrupt antinociceptive but not cardiovascular aversive conditional responses.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1994
View 4 Excerpts
Method Support
Highly Influenced