• Corpus ID: 16555841

Circuit and Behavioral Analysis of Klinotaxis in Caenorhabditis elegans

@inproceedings{McCormick2013CircuitAB,
  title={Circuit and Behavioral Analysis of Klinotaxis in Caenorhabditis elegans},
  author={Kathryn E. McCormick},
  year={2013}
}
Original approval signatures are on file with the University of Oregon Graduate School. Title: Circuit and Behavioral Analysis of Klinotaxis in Caenorhabditis elegans The nervous system is a complex organ that functions in most metazoans to sense and respond to a constantly changing world. How the nervous system does this is a major focus of systems-level neuroscience. This dissertation investigates the neural basis of the sensorimotor transformation underlying a spatial orientation strategy in… 
Information Flow through a Model of the C. elegans Klinotaxis Circuit
TLDR
Despite large variations in the neural parameters of individual circuits, the overall information flow architecture circuit is remarkably consistent across the ensemble, suggesting structural connectivity is not necessarily predictive of effective connectivity and information flow analysis captures general principles of operation for the klinotaxis circuit.
An Integrated Neuromechanical Model of Steering in C. elegans
TLDR
Analysis of the sensorimotor transformation and phasic stimulation experiments provides evidence that the principles of operation for steering discussed in the model are relevant for steering in the worm.

References

SHOWING 1-10 OF 78 REFERENCES
Evolution and Analysis of Minimal Neural Circuits for Klinotaxis in Caenorhabditis elegans
TLDR
A minimalistic neural network, comprised of an ON-OFF pair of chemosensory neurons and a pair of neck muscle motor neurons, is sufficient to generate realistic klinotaxis behavior, suggesting that the model may be operating according to principles similar to those of the biological network.
High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments
TLDR
A microfluidic system to analyze Caenorhabditis elegans behavior in defined temporal and spatial stimulus patterns and identified both expected and unexpected responses in wild-type worms and sensory mutants by quantifying dozens of behavioral parameters.
Step Response Analysis of Thermotaxis in Caenorhabditis elegans
TLDR
Overall, however, turning probability was modulated in a manner consistent with a role for turning behavior in thermal migration, suggesting that sensory systems for thermotaxis and chemotaxis may converge on a common behavioral mechanism.
Parallel Use of Two Behavioral Mechanisms for Chemotaxis in Caenorhabditis elegans
TLDR
Using laser ablation of individual neurons to examine the underlying neural circuit, it is found the ASE sensory neurons and AIZ interneurons are essential for both the pirouette and weathervane mechanisms in chemotaxis to NaCl.
Thermotaxis is a Robust Mechanism for Thermoregulation in Caenorhabditis elegans Nematodes
TLDR
It is suggested that, similar to biochemical networks, animals evolve behavioral strategies that are robust, rather than strategies that rely on fine tuning of specific behavioral parameters.
Connecting a Connectome to Behavior: An Ensemble of Neuroanatomical Models of C. elegans Klinotaxis
TLDR
This paper develops a neuroanatomically-grounded model of salt klinotaxis, a form of chemotaxis in which changes in orientation are directed towards the source through gradual continual adjustments.
Microfluidic Devices for Analysis of Spatial Orientation Behaviors in Semi-Restrained Caenorhabditis elegans
TLDR
The fabrication and use of microfluidic devices for investigating spatial orientation behaviors in nematode worms are described, identifying previously uncharacterized aspects of the behavioral mechanisms underlying chemotaxis, osmotic avoidance, and thermotaxis in this organism.
Chemosensory behavior of semi-restrained Caenorhabditis elegans.
TLDR
It is shown that restrained C. elegans display behaviors comparable to those of freely moving worms, and the chemosensory response of wild-type glued animals to changes in salt concentration is similar to that of freelyMoving animals.
The Fundamental Role of Pirouettes in Caenorhabditis elegans Chemotaxis
TLDR
It is suggested that chemotaxis is produced by a series of pirouettes that reorient the animal to the gradient, and the pirouette model of C. elegans chemot axis is sufficient and general.
...
1
2
3
4
5
...