Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.

@article{Murdoch2001CircletailAN,
  title={Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation.},
  author={Jennifer N. Murdoch and Rivka A. Rachel and Saleh Shah and Friedrich Beermann and Philip Stanier and Carol Ann Mason and Andrew J Copp},
  journal={Genomics},
  year={2001},
  volume={78 1-2},
  pages={55-63}
}
Circletail (Crc) is a new mouse mutant that exhibits a severe form of neural tube defect, craniorachischisis, in which almost the entire neural tube fails to close. This phenotype is seen in very few other mutants, the best characterized of which is loop-tail (Ltap(Lp), referred to hereafter as Lp). We tested the possibility of allelism between Lp and Crc by intercrossing Lp/+ and Crc/+mice. A proportion of double heterozygotes (Lp/+,Crc/+) exhibit craniorachischisis, revealing failure of… CONTINUE READING