Circadian variations in the activities of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in the liver of control and streptozotocin-induced diabetic rats.

@article{Ulusu2005CircadianVI,
  title={Circadian variations in the activities of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase in the liver of control and streptozotocin-induced diabetic rats.},
  author={N. Nuray Ulusu and Gul Ozbey and Berivan Tandoğan and A Gunes and Deniz Durakoglugil and Cimen Karasu and Canan Uluoğlu and Hakan Zengil},
  journal={Chronobiology international},
  year={2005},
  volume={22 4},
  pages={
          667-77
        }
}
The aim of this study was to examine: the 24 h variation of 6-phosphogluconate dehydrogenase and glucose-6-phosphate dehydrogenase activities, key enzymes for the maintenance of intracellular NADPH concentration, in rat liver in control and streptozotocin-induced diabetic animals. Adult male rats were fed ad libitum and synchronized on a 12:12 h light-dark cycle (lights on 08:00 h). One group of animals was treated with streptozotocin (STZ, 55 mg/kg, intraperitoneal) to induce experimental… CONTINUE READING

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