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    International journal of…

Circadian variations in hepatotoxicity of carbon tetrachloride in mice.

  title={Circadian variations in hepatotoxicity of carbon tetrachloride in mice.},
  author={Małgorzata Skrzypińska-Gawrysiak and Jerzy K. Piotrowski and Stanislaw Sporny},
  journal={International journal of occupational medicine and environmental health},
  volume={13 2},
Male mice of Balb/C strain were administered i.p. carbon tetrachloride, in single doses of 35 and 145 mg/kg, given at variable time of the day. The activity of alanine aminotransferase (ALAT) in serum, and the hepatic level of malondialdehyde (MDA) as well as reduced glutathione (GSH) were adopted as indicators of toxicity. In selected groups, liver histopathology was carried out. The experiment was performed in two series differing in the dynamics of observations. A differentiation of the… CONTINUE READING