Circadian variation of growth factor levels in platelet-rich plasma.

  title={Circadian variation of growth factor levels in platelet-rich plasma.},
  author={Katsuya Aoto and Akihiro Kanamori and Tomokazu Yoshioka and Kenta Uemura and Masataka Sakane and Masashi Yamazaki},
  journal={Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine},
  volume={24 6},
OBJECTIVE The influence of circadian rhythms has recently been considered in advanced studies of chronopharmacology and chronotherapeutics. Although emerging studies have reported the usefulness of platelet-rich plasma (PRP), no reports have described the diurnal variations in PRP growth factor levels. In the present study, we hypothesized that growth factor levels in PRP show a significant diurnal variation. DESIGN Controlled laboratory study. SETTING Institutional. PARTICIPANTS Ten… CONTINUE READING