Circadian variation in allergen and nonspecific bronchial responsiveness in asthma.

@article{Jarjour1999CircadianVI,
  title={Circadian variation in allergen and nonspecific bronchial responsiveness in asthma.},
  author={Nizar N Jarjour},
  journal={Chronobiology international},
  year={1999},
  volume={16 5},
  pages={631-9}
}
In a majority of patients, exacerbations of asthma occur more frequently during the night than day. Many hypotheses have been proposed to explain such variation in asthma. The airways of asthmatic persons are characterized by an abnormal degree of inflammation and bronchial hyperresponsiveness to both nonspecific and specific challenges. Studies of both children and adults with asthma document marked circadian rhythmicity in the response of airways to bronchial challenges with histamine… CONTINUE READING

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