Circadian topology of metabolism

@article{Bass2012CircadianTO,
  title={Circadian topology of metabolism},
  author={Joseph T Bass},
  journal={Nature},
  year={2012},
  volume={491},
  pages={348-356}
}
  • J. Bass
  • Published 14 November 2012
  • Biology
  • Nature
Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light–dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand… 
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494 Citations
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494 Citations

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mounting evidence is questioning the absolute necessity of transcription-based oscillators for circadian rhythmicity, supported by the recent discovery of oxidation-reduction cycles of peroxiredoxin proteins, which persist even in the absence of transcription.
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It is suggested that temperature compensation is actually a subset of a larger phenomenon, namely metabolic compensation, which maintains the frequency of circadian oscillators in response to a host of factors that impinge on metabolism and would otherwise destabilize these clocks.
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The modulatory relationship between plant biological clock and photosynthesis metabolites indicates the potential advantage of biological rhythm theory in agricultural applications.
The molecular basis of metabolic cycles and their relationship to circadian rhythms
  • J. Mellor
  • Biology
    Nature Structural &Molecular Biology
  • 2016
TLDR
The molecular basis of the metabolic and gene-expression oscillations in the yeast Saccharomyces cerevisiae are explored, as well as how they relate to other biological time-keeping mechanisms, such as circadian rhythms.
Metabolic rhythms: A framework for coordinating cellular function
  • H. Causton
  • Biology
    The European journal of neuroscience
  • 2018
TLDR
Features of yeast respiratory oscillations are described, which share many features with daily and 12 hr cellular oscillations in animal cells, and this relatively simple system enables the analysis of dynamic rhythmic changes in metabolism, independent of Cellular oscillations that are a product of the circadian transcription‐translation feedback loop.
The circadian system as an organizer of metabolism.
Circadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome
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Daily rhythms in liver arising from synergistic action of both the cell-autonomous circadian clock and feeding–fasting driven molecular programs are thought to temporally coordinate metabolism to the appropriate time of the day to sustain metabolic homeostasis.
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