Circadian timing in cancer treatments.

  title={Circadian timing in cancer treatments.},
  author={Francis A L{\'e}vi and Alper Okyar and Sandrine Dulong and Pasquale F Innominato and Jean Clairambault},
  journal={Annual review of pharmacology and toxicology},
The circadian timing system is composed of molecular clocks, which drive 24-h changes in xenobiotic metabolism and detoxification, cell cycle events, DNA repair, apoptosis, and angiogenesis. The cellular circadian clocks are coordinated by endogenous physiological rhythms, so that they tick in synchrony in the host tissues that can be damaged by anticancer… CONTINUE READING
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