Circadian rhythms on hypothalamic-pituitary-adrenal axis hormones and cytokines of collagen induced arthritis in rats.

@article{Li2004CircadianRO,
  title={Circadian rhythms on hypothalamic-pituitary-adrenal axis hormones and cytokines of collagen induced arthritis in rats.},
  author={Shao Li and Aiping Lu and Biao Li and Yongyan Wang},
  journal={Journal of autoimmunity},
  year={2004},
  volume={22 4},
  pages={277-85}
}
This study is designed to identify whether circadian rhythms of the hormones of the hypothalamic-pituitary-adrenal (HPA) axis are associated with corresponding circadian fluctuations in cytokines in a rat model of collagen-induced arthritis (CIA). CIA is induced in Wistar rats by an intradermal injection of bovine type II collagen emulsified with complete adjuvant at the left foot. On day 33, in both the CIA and the control rats, circulating adrenocorticotropin hormone (ACTH) and corticosterone… CONTINUE READING

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Cellular Rhythms and Networks

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