Circadian rhythms influence cardiovascular disease differently in males and females: role of sex and gender

@article{GlenPyle2018CircadianRI,
  title={Circadian rhythms influence cardiovascular disease differently in males and females: role of sex and gender},
  author={W Glen Pyle and Tami A Martino},
  journal={Current Opinion in Physiology},
  year={2018}
}
Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility
TLDR
The CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex and single nucleotide polymorphisms of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 did not significantly differ between the sexes.
Circadian influence on the microbiome improves heart failure outcomes.
The Clock Mechanism Influences Neurobiology and Adaptations to Heart Failure in Clock∆19/∆19 Mice With Implications for Circadian Medicine
TLDR
Evidence is found that the circadian mechanism is an important regulator of healthy cognitive system neurobiology and influences neurobiological gene adaptations to HF at a cellular level, which has clinical relevance as patients with HF often present with concurrent neurocognitive impairments.
Circadian Rhythm of Deaths in a Cardiology Department: A Five-Year Analysis
TLDR
The daytime oscillations in mortality in hospitalized patients with cardiovascular diseases follows a circadian biphasic pattern and was present regardless from the place of death (conventional ward or cardiac intensive care unit) and also throughout the four seasons.
DNA methylation of circadian genes and markers of cardiometabolic risk in female hospital workers: An exploratory study
TLDR
The findings suggest that the relationship between DNA methylation of circadian genes and cardiometabolic risk differs by day and night shift worker status, which may contribute to mechanisms of increased risk of CVD observed among night shift workers.
Hemostasis and Cognitive Brain: 5P-Medicine and Chronotherapy of Arterial Hypertension
TLDR
The results suggest increased mortality in evening types and increased levels of cardiometabolic risk factors in these groups and new insights into the molecular and cellular pathways by which cardiovascular events occur in a daily oscillatory pattern will help create a new therapeutic approach to CVD treatment.
GENDER-SPECIFIC DIFFERENCES OF CARDIAC VEGETATIVE CONTROL IN ADRENALINE-INDUCED NECROSIS AND LIGHT DEPRIVATION
TLDR
Light deprivation has different effects on baseline sympathetic/parasympathetic balance in males and females, i.e. increased parasympathy control of heart rhythm in males, and maintenance of sympathetic/ parASYmpathetic Balance in females.
Clock Genes Disruption in the Intensive Care Unit
TLDR
Light therapy as well as melatonin treatment could reduce the impact of ICU stay period in biological clock, thereby improving patients’ recovery and probably, circadian resynchronization restoring clock gene expression could lead to a better clinical evolution of the patient.
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The profound adverse impact of disturbed circadian rhythms and sleep on the cardiovascular system is described, including recovery from myocardial infarction in acute care settings, shift work and heart disease, sleep disorders including obstructive sleep apnea, and cardiovascular pathophysiology associated with disturbed nocturnal blood pressure profiles are described.
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The intriguing question whether female sex protects against clock-mediated accelerated pathological remodelling of the aging heart is tackled, with results corroborating the protective role of the female sex hormones along with the importance of Clock in age-dependent cardiomyopathy.
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