Circadian rhythms, jet lag, and chronobiotics: an overview.

  title={Circadian rhythms, jet lag, and chronobiotics: an overview.},
  author={Peter H. Redfern and David S. Minors and James Waterhouse},
  journal={Chronobiology international},
  volume={11 4},
This overview considers the origins of jet lag in terms of altered circadian rhythmicity. The properties required of a chronobiotic--an agent to cause phase adjustment of the body clock--are discussed, and an account is given of the major candidates at the present time: light, melatonin, activity, and benzodiazepines. It is concluded that current knowledge indicates that a combination of factors is likely to be most effective. 
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