Circadian rhythms, aging, and life span in mammals.

@article{Froy2011CircadianRA,
  title={Circadian rhythms, aging, and life span in mammals.},
  author={Oren Froy},
  journal={Physiology},
  year={2011},
  volume={26 4},
  pages={
          225-35
        }
}
  • O. Froy
  • Published 1 August 2011
  • Medicine
  • Physiology
Resetting the circadian clock leads to well being and increased life span, whereas clock disruption is associated with aging and morbidity. Increased longevity and improved health can be achieved by different feeding regimens that reset circadian rhythms and may lead to better synchrony in metabolism and physiology. This review focuses on recent findings concerning the relationships between circadian rhythms, aging attenuation, and life-span extension in mammals. 
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References

SHOWING 1-10 OF 204 REFERENCES

Metabolism and the control of circadian rhythms.

A simple model, integrating biochemical, cellular, and physiologic data, is presented to account for the connection of cellular metabolism and circadian rhythm.

Aging in the circadian system: Considerations for health, disease prevention and longevity

Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited

It is found that the deviation of tau from 24 h was inversely related to the lifespan in laboratory mouse strains, and in other rodent and primate species, supporting the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity.

Effect of feeding regimens on circadian rhythms: Implications for aging and longevity

The hypothesis that the beneficial effects exerted by these feeding regimens could be mediated, at least in part, through resetting of the circadian clock, thus leading to synchrony in metabolism and physiology is raised.

Aging and circadian rhythms.

Circadian clock resetting in the mouse changes with age

The responsiveness of the circadian clock with age is attenuated to some, but not all stimuli, which suggests that not all clock stimuli loose their effectiveness with age, and that it may be possible to compensate for deficits in clock performance by enhancing the strength of those stimulus pathways which are intact.

The Significance of Circadian Organization for Longevity in the Golden Hamster

Longevity in hamsters is decreased with a noninvasive disruption of rhythmicity and is increased in older animals given suprachiasmatic implants that restore higher amplitude rhythms, substantiating the importance of the temporal organization of physiology and behavior provided by the circadian clock to the health and longevity of an organism.

Circadian rhythms from flies to human

The existence of a circadian clock in humans had been postulated for decades, but an understanding of the molecular mechanisms has required the full complement of research tools, and researchers turned to genetically tractable model organisms such as Drosophila.

Signaling to the circadian clock: plasticity by chromatin remodeling.

Age‐Related Changes of Circadian Rhythms and Sleep‐Wake Cycles

OBJECTIVES: To compare relationships between the sleep‐wake cycle and endogenous circadian rhythms in young and older adults and to examine correlates between evening naps and circadian rhythms in…
...