Circadian rhythmicity of body temperature and metabolism

  title={Circadian rhythmicity of body temperature and metabolism},
  author={Roberto Refinetti},
  pages={321 - 362}
ABSTRACT This article reviews the literature on the circadian rhythms of body temperature and whole-organism metabolism. The two rhythms are first described separately, each description preceded by a review of research methods. Both rhythms are generated endogenously but can be affected by exogenous factors. The relationship between the two rhythms is discussed next. In endothermic animals, modulation of metabolic activity can affect body temperature, but the rhythm of body temperature is not a… Expand
Diet-altered body temperature rhythms are associated with altered rhythms of clock gene expression in peripheral tissues in vivo.
Diet-altered body temperature rhythms differentially affected the profiles of clock genes, Hsp90, and Cirbp expression in peripheral tissues, and the association with the amplitude of metabolic gene expression is limited to the white adipose tissue. Expand
The effects of housing density on mouse thermal physiology depend on sex and ambient temperature
Single housing is more sensitive than group housing for detecting thermal physiology phenotypes and amplifies the effects of fasting or a cold environment, and male and female mice utilize different thermoregulatory strategies to respond to single housing. Expand
Dissociation of Subjective and Objective Alertness During Prolonged Wakefulness
The results indicate that the perceived degree of decline in alertness is temporally dissociated with the actual decline in objective vigilance with increased duration of wakefulness. Expand
Body Temperature Frequency Distributions: A Tool for Assessing Thermal Performance in Endotherms?
There is increasing recognition that rather than being fully homeothermic, most endotherms display some degree of flexibility in body temperature. However, the degree to which this occurs variesExpand


Homeostasis and Circadian Rhythmicity in the Control of Body Temperature a
  • R. Refinetti
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
  • 1997
Research during the last six years provides strong support for the hypothesis of the separate control of body temperature by the homeostatic and the circadian system. Expand
The circadian rhythm of body temperature
This article reviews the literature on the circadian rhythm of body temperature. It starts with a description of the typical pattern of oscillation under standard laboratory conditions, withExpand
Circadian Systems and Metabolism
A mathematical model based on the chemical reactions of photosynthesis demonstrates that metabolism as such may generate rhythmicity in the circadian range and two additional models look at the possible function of feedback loops outside of the circadian oscillator. Expand
The circadian rhythm of body temperature.
This paper reviews the literature on the circadian rhythm of body temperature (CRT) and a section on the nervous control of the CRT is followed by summary and conclusions. Expand
Circadian timing of metabolism in animal models and humans
This work focuses primarily on metabolic disorders such as obesity and type 2 diabetes, although circadian misalignments (shiftwork or ‘social jet lag’) have also been associated with the aetiology of human malignancies. Expand
Circadian regulation of metabolism.
Current understanding of the interplay between circadian clocks and metabolism is reviewed, in addition to the pathophysiologic consequences of disruption of this molecular mechanism, in terms of cardiometabolic disease development. Expand
The Circadian Rhythm of Thermoregulation in Japanese Quail. II. Multioscillator Control
It is proposed that the central circadian system (suprachiasmatic nuclei?) acts as a complex pacemaker that is functionally organized as two sets of oscillators and that circadian input from the eyes is necessary to preserve the integrity of this complexpacemaker. Expand
Circadian physiology of metabolism
These findings highlight an integrative role of circadian rhythms in physiology and offer a new perspective for treating chronic diseases in which metabolic disruption is a hallmark. Expand
Rhythms of Mammalian Body Temperature Can Sustain Peripheral Circadian Clocks
It is postulate that both endogenous and environmental temperature cycles can participate in the synchronization of peripheral clocks in mammals. Expand
The Circadian Rhythm of Core Temperature: Origin and some Implications for Exercise Performance
This review first examines reliable and convenient ways of measuring core temperature for studying the circadian rhythm, concluding that measurements of rectal and gut temperature fulfil theseExpand