Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.

@article{Besing2015CircadianRO,
  title={Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.},
  author={Rachel C. Besing and Jodi R Paul and Lauren M Hablitz and Courtney O Rogers and Russell L. Johnson and Martin Elliot Young and Karen L Gamble},
  journal={Journal of biological rhythms},
  year={2015},
  volume={30 2},
  pages={155-60}
}
The suprachiasmatic nucleus (SCN) drives and synchronizes daily rhythms at the cellular level via transcriptional-translational feedback loops comprising clock genes such as Bmal1 and Period (Per). Glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, phosphorylates at least 5 core clock proteins and shows diurnal variation in phosphorylation state (inactivation) of the GSK3β isoform. Whether phosphorylation of the other primary isoform (GSK3α) varies across the subjective day-night… CONTINUE READING
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