Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome.

@article{Okawa2007CircadianRS,
  title={Circadian rhythm sleep disorders: characteristics and entrainment pathology in delayed sleep phase and non-24-h sleep-wake syndrome.},
  author={Masako Okawa and Makoto Uchiyama},
  journal={Sleep medicine reviews},
  year={2007},
  volume={11 6},
  pages={
          485-96
        }
}
  • M. Okawa, M. Uchiyama
  • Published 1 December 2007
  • Psychology, Medicine, Biology
  • Sleep medicine reviews

Figures and Tables from this paper

Delayed Sleep-Phase Type

Circadian tau differences and rhythm associations in Delayed Sleep-Wake Phase Disorder and sighted Non-24-Hour Sleep-Wake Rhythm Disorder.

TLDR
People with DSWPD and N24SWD exhibit significantly longer biological circadian rhythm period lengths compared to controls suggesting abnormal phase relationship between biological rhythms and behavioral sleep period or potentially conditioned sleep onset insomnia.

Advances in the pharmacological management of non-24-h sleep-wake disorder

TLDR
The authors review the pharmacological therapies including exogenous melatonin and melatonin receptor agonists for the management of non-24 and introduce a historical report about the effects of melatonin on the phase shift and entrainment for blind individuals with the free-running circadian rhythm.

Circadian rhythm sleep disorders: An update

TLDR
DSPD and ASPD are the common primary circadian rhythm disorders and the recent developments in the pathogenesis, diagnosis, and management of CRSDs are discussed.

Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation

TLDR
Low dose of APZ advanced the sleep rhythm and reduced nocturnal sleep time in the subjects with delayed sleep phase syndrome (DSPS), and this medication would become a new therapeutic option for these patients.

The etiology of delayed sleep phase disorder.

...

References

SHOWING 1-10 OF 110 REFERENCES

Poor compensatory function for sleep loss as a pathogenic factor in patients with delayed sleep phase syndrome.

TLDR
It is suggested that poor compensatory function for sleep loss predisposes DSPS patients to failure to reset their sleep phase and provides implications for understanding not only the pathophysiology of DSPS but also the biological basis for why some people can change their sleep schedule easily according to personal or social demands while others cannot.

The delayed sleep phase syndrome: clinical and investigative findings in 14 subjects.

TLDR
The syndrome causes severe disruption to education, work and family life, and different patterns of sleep phase delay seen in the syndrome include stable, progressive, irregular and non-24 hour sleep-wake cycles.

Circadian rhythm sleep disorders in adolescents: Clinical trials of combined treatments based on chronobiology

TLDR
A step‐by‐step procedure of combined treatments for the circadian rhythm sleep disorders is proposed, based on clinical studies of patients with delayed sleep phase syndrome and non‐24‐h sleep–wake rhythm.

Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment.

TLDR
The case of a 41-year-old sighted man with non-24-hour sleep-wake syndrome is presented and it is revealed that the patient appeared to be subsensitive to bright light.

Clinical characteristics of circadian rhythm sleep disorders

TLDR
Difficulty in adapting to social life was more severe in patients with non‐24 than in those with DSPS, and it was of psychiatric interest that a considerable number of patients had depressive states in the course of their circadian rhythm sleep disorders.

Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia.

TLDR
A new syndrome called "delayed sleep phase insomnia" is described, which is proposed to be a disorder of the circadian sleep-wake rhythm in which the "advance" portion of the phase response curve is small.

Familial advanced sleep-phase syndrome: A short-period circadian rhythm variant in humans

TLDR
Three kindreds with a profound phase advance of the sleep–wake, melatonin and temperature rhythms associated with a very short τ represent a well-characterized familial circadian rhythm variant in humans and provide a unique opportunity for genetic analysis of human circadian physiology.

Larger phase angle between sleep propensity and melatonin rhythms in sighted humans with non-24-hour sleep-wake syndrome.

TLDR
It was postulated that Non-24 sufferers' delayed SP onset relative to the circadian pacemaker may accelerate the light-induced phase-delay, leading to sleep-wake cycle that is longer than 24 hours.

Melatonin Rhythms in Delayed Sleep Phase Syndrome

TLDR
The alteration of phase angle between melatonin rhythm and sleep phase suggested that not only the delay of the circadian clock but also a functional disturbance of the sleep-wake mechanism underlies delayed sleep phase syndrome.
...