Circadian rhythm modulates long-term potentiation induced at CA1 in rat hippocampal slices

@article{Nakatsuka2014CircadianRM,
  title={Circadian rhythm modulates long-term potentiation induced at CA1 in rat hippocampal slices},
  author={Hiroki Nakatsuka and Kiyohisa Natsume},
  journal={Neuroscience Research},
  year={2014},
  volume={80},
  pages={1-9}
}
Circadian rhythm affects neuronal plasticity. Consistent with this, some forms of synaptic long-term potentiation (LTP) are modulated by the light/dark cycle (LD cycle). For example, this type of modulation is observed in hippocampal slices. In rodents, which are nocturnal, LTP is usually facilitated in the dark phase, but the rat hippocampal CA1 is an exception. The reason why LTP in the dark phase is suppressed in CA1 remains unknown. Previously, LTP was induced with high-frequency… CONTINUE READING