Circadian rhythm in sensitivity of glucose metabolism to insulin in rat soleus muscle.

@article{Leighton1988CircadianRI,
  title={Circadian rhythm in sensitivity of glucose metabolism to insulin in rat soleus muscle.},
  author={Brendan Leighton and J. Kowalchuk and R. A. John Challiss and Eric A. Newsholme},
  journal={The American journal of physiology},
  year={1988},
  volume={255 1 Pt 1},
  pages={E41-5}
}
This study determined whether the sensitivity of glucose metabolism to insulin in skeletal muscle varies during a 24-h period. Soleus muscles were isolated from ad libitum-fed rats killed at 0900, 1600, 2100, and 0300. The animal house was illuminated between 0800 and 2000. The sensitivities of glycolysis (which is an excellent index of glucose transport) and glycogen synthesis to insulin were greatest in muscles isolated at 0900 and 2100. Marked decreases in sensitivities of both processes to… CONTINUE READING