Circadian rhythm in pain, stiffness, and manual dexterity in rheumatoid arthritis: relation between discomfort and disability.

@article{Bellamy1991CircadianRI,
  title={Circadian rhythm in pain, stiffness, and manual dexterity in rheumatoid arthritis: relation between discomfort and disability.},
  author={Nicholas Bellamy and Robert B. Sothern and J. Campbell and W. Watson Buchanan},
  journal={Annals of the Rheumatic Diseases},
  year={1991},
  volume={50},
  pages={243 - 248}
}
Fourteen patients with rheumatoid arthritis (RA) self rated their pain and stiffness on separate 10 cm visual analogue scales and performed bead intubation coordinometry (BIC) on six occasions each day for seven consecutive days. In addition, 14 healthy controls matched for age and sex also performed BIC measurements according to the same schedule. Data were analysed using least squares and cosine vector techniques. Significant circadian rhythms in patients with RA were detected in pain… 
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