Circadian rhythm genetics: from flies to mice to humans

@article{WagerSmith2000CircadianRG,
  title={Circadian rhythm genetics: from flies to mice to humans},
  author={Karen Wager-Smith and Steve A. Kay},
  journal={Nature Genetics},
  year={2000},
  volume={26},
  pages={23-27}
}
A successful genetic dissection of the circadian regulation of behaviour has been achieved through phenotype-driven mutagenesis screens in flies and mice. Cloning and biochemical analysis of these evolutionarily conserved proteins has led to detailed molecular insight into the clock mechanism. Few behaviours enjoy the degree of understanding that exists for circadian rhythms at the genetic, cellular and anatomical levels. The circadian clock has so eagerly spilled her secrets that we may soon… Expand
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