Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.

Abstract

Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were investigated by electron microscopy… (More)
DOI: 10.1096/fj.201700141RR

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