Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters.

@article{Martino2008CircadianRD,
  title={Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters.},
  author={T. Martino and G. Oudit and A. Herzenberg and N. Tata and M. Koletar and G. Kabir and D. Belsham and P. Backx and M. Ralph and M. Sole},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={294 5},
  pages={
          R1675-83
        }
}
  • T. Martino, G. Oudit, +7 authors M. Sole
  • Published 2008
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
Sleep deprivation, shift work, and jet lag all disrupt normal biological rhythms and have major impacts on health; however, circadian disorganization has never been shown as a causal risk factor in organ disease. We now demonstrate devastating effects of rhythm disorganization on cardiovascular and renal integrity and that interventions based on circadian principles prevent disease pathology caused by a short-period mutation (tau) of the circadian system in hamsters. The point mutation in the… Expand
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