Circadian rhythm and joint stiffness/destruction in rheumatoid arthritis

@article{Yoshida2015CircadianRA,
  title={Circadian rhythm and joint stiffness/destruction in rheumatoid arthritis},
  author={Kohsuke Yoshida and Teppei Hashimoto and Yoshitada Sakai and Akira Hashiramoto},
  journal={International Journal of Clinical Rheumatology},
  year={2015},
  volume={10},
  pages={335-344}
}
In patients with rheumatoid arthritis, joint stiffness and pain levels reach peak in the morning, which is a characteristic symptom with diurnal fluctuation. In human, several types of hormone secretion, cytokine and antibody production are accelerated during night time as compared with those of day time, and these immune systems are partially controlled by circadian clock genes that regulate circadian rhythm. In this review, we focus on the interaction between circadian clock genes, immune… Expand
2 Citations
Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs
TLDR
The expressions of the clock genes in leukocytes could be useful as novel biomarkers predicting disease activities and therapeutic efficacies for bDMARDs in RA treatments. Expand
TNF-α induces expression of the circadian clock gene Bmal1 via dual calcium-dependent pathways in rheumatoid synovial cells.
TLDR
A novel role is determined in inducing Bmal1 via dual calcium dependent pathways; Rorα was up-regulated in the presence of Ca2+ influx and Rev-erbα was down- regulated in the absence of that; it is proposed that inhibition of p300/CBP could be new therapeutic targets for RA. Expand

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