Circadian rhythm and cardiovascular disease

  title={Circadian rhythm and cardiovascular disease},
  author={Elizabeth Shaw and Geoffrey H Tofler},
  journal={Current Atherosclerosis Reports},
  • E. ShawG. Tofler
  • Published 14 June 2009
  • Medicine, Biology
  • Current Atherosclerosis Reports
The demonstration of a circadian variation in frequency of onset of myocardial infarction, sudden cardiac death, and stroke provides an opportunity to gain insight into the mechanism of transformation from chronic stable to acute unstable manifestation of cardiovascular disease. Contributing physiologic changes that exhibit a morning peak include arterial pressure, heart rate, and vascular tone, which promote plaque rupture, together with increased platelet reactivity and reduced fibrinolytic… 

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Circadian Variation of Stroke Onset: A Hospital-Based Study

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The finding that the frequency of sudden cardiac death is increased in the morning is compatible with hypotheses that sudden cardiacDeath results from ischemia or from a primary arrhythmic event, and further study of the physiologic changes occurring in theMorning may provide new information supporting or refuting these hypotheses.

Circadian variation and triggers of onset of acute cardiovascular disease.

Recognition of the circadian variation--and the possibility of frequent triggering--of onset of acute disease suggests the need for pharmacologic protection of patients during vulnerable periods, and provides clues to mechanism, which may lead to improved methods of prevention.

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  • T. Giles
  • Medicine
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension
  • 2006
Acc ambulatory blood pressure monitoring is superior to clinic blood pressure in predicting cardiovascular morbidity and mortality, and this suggests that 24-h blood pressure control may be necessary to gain complete benefit from blood pressure-lowering therapy.

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