Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.

  title={Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients.},
  author={Zhiliang Yang and Ayumi Matsumoto and Kazuhiro Nakayama and Eriko F. Jimbo and Karin Kojima and Koh-Ichi Nagata and Sadahiko Iwamoto and Takanori Yamagata},
  journal={Brain & development},
  volume={38 1},
BACKGROUND The genetic background of autism spectrum disorder (ASD) is considered a multi-genetic disorder with high heritability. Autistic children present with a higher prevalence of sleep disorders than has been observed in children with normal development. Some circadian-relevant genes have been associated with ASD (e.g., PER1, PER2, NPAS2, MTNR1A, and MTNR1B). METHODS We analyzed 28 ASD patients (14 with sleep disorders and 14 without) and 23 control subjects of Japanese descent. The… CONTINUE READING
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