Circadian release of hypothalamic norepinephrine in rats in vivo is depressed during early L-lysine deficiency.

@article{Smriga2000CircadianRO,
  title={Circadian release of hypothalamic norepinephrine in rats in vivo is depressed during early L-lysine deficiency.},
  author={Miro Smriga and Masato Mori and Kunio Torii},
  journal={The Journal of nutrition},
  year={2000},
  volume={130 6},
  pages={1641-3}
}
Rats rapidly recognize an amino acid-deficient diet, presumably via central mechanisms that involve hypothalamic circuits. We evaluated the effects of a deficiency of the essential amino acid, L-lysine, on the ventromedial hypothalamus (VMH) norepinephrine (NE) circadian release in free-moving, nonstressed rats. A dialysis probe was implanted into the VMH of male Wistar rats. Continuous microdialysis measurement was done during the first 26 h of L-lysine (Lys) deficiency in rats that had free… CONTINUE READING

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