Circadian regulation of prion protein messenger RNA in the rat forebrain: a widespread and synchronous rhythm

@article{Cagampang1999CircadianRO,
  title={Circadian regulation of prion protein messenger RNA in the rat forebrain: a widespread and synchronous rhythm},
  author={F. A. Cagampang and S. Whatley and A. Mitchell and J. Powell and C. Coen},
  journal={Neuroscience},
  year={1999},
  volume={91},
  pages={1201-1204}
}
  • F. A. Cagampang, S. Whatley, +2 authors C. Coen
  • Published 1999
  • Biology, Medicine
  • Neuroscience
  • Although the expression of the normal prion protein in the host is critical to the development of transmissible spongiform encephalopathies, the physiological role of this protein and the processes regulating its expression remain obscure. We now report that the messenger RNA for the prion protein is regulated in the rat brain in a marked circadian manner not only in the suprachiasmatic nuclei, the principal site for the generation of mammalian circadian rhythms, but also in other forebrain… CONTINUE READING
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