Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells.

@article{Liu2002CircadianRO,
  title={Circadian regulation of nocturnin transcription by phosphorylated CREB in Xenopus retinal photoreceptor cells.},
  author={Xiaorong Liu and Carla B. Green},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 21},
  pages={7501-11}
}
Although CLOCK/BMAL1 heterodimers have been implicated in transcriptional regulation of several rhythmic genes in vitro through E-box sequence elements, little is known about how the circadian clock regulates rhythmic genes with diverse phases in vivo. The gene nocturnin is rhythmically transcribed in Xenopus retinal photoreceptor cells, which contain endogenous circadian clocks. Transcription of nocturnin peaks in these cells in the middle of the night, while CLOCK/BMAL1 activity peaks during… CONTINUE READING

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