Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge.

@article{Robertson2009CircadianRO,
  title={Circadian regulation of Kiss1 neurons: implications for timing the preovulatory gonadotropin-releasing hormone/luteinizing hormone surge.},
  author={Jessica L Robertson and Donald K. Clifton and Horacio O de la Iglesia and Robert A Steiner and Alexander S Kauffman},
  journal={Endocrinology},
  year={2009},
  volume={150 8},
  pages={3664-71}
}
The preovulatory GnRH/LH surge depends on the presence of estradiol (E(2)) and is gated by a circadian oscillator in the suprachiasmatic nucleus (SCN) that causes the surge to occur within a specific temporal window. Although the mechanisms by which the clock times the LH surge are unclear, evidence suggests that the SCN is linked to GnRH neurons through a multisynaptic pathway that includes neurons in the anteroventral periventricular nucleus (AVPV). Recently, Kiss1 neurons in the AVPV have… CONTINUE READING

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Evidence that kisspeptin neurons in the AVPV form part of a bisynaptic pathway connecting suprachiasmatic vasopressin neurons with preoptic GnRH cells

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