Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm.

@article{vanCauter1992CircadianMO,
  title={Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm.},
  author={Eve van Cauter and E T Shapiro and Hartmut Tillil and Kenneth S. Polonsky},
  journal={The American journal of physiology},
  year={1992},
  volume={262 4 Pt 1},
  pages={
          E467-75
        }
}
To determine whether glucose and insulin responses to a mixed meal are influenced by time of day irrespective of duration of prior fast, eight normal subjects (4 males, 4 females) were studied on two separate occasions, involving ingestion of identical meals at either 6- or 12-h intervals. [] Key Method The 24-h profiles of plasma glucose, serum insulin, and plasma C-peptide were obtained at 20-min intervals.

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