Circadian gene expression is suppressed during sevoflurane anesthesia and the suppression persists after awakening.

@article{Kobayashi2007CircadianGE,
  title={Circadian gene expression is suppressed during sevoflurane anesthesia and the suppression persists after awakening.},
  author={Katsuya Kobayashi and Ken Takemori and Atsuhiro Sakamoto},
  journal={Brain research},
  year={2007},
  volume={1185},
  pages={1-7}
}
General anesthesia is routinely used as a surgical procedure and its safety has been endorsed by clinical outcomes; however, its effects at the molecular level have not been elucidated. We previously showed that inhalation anesthesia affects the expression of 1.5% of 10,000 genes, which included so-called circadian genes. In the current study, we confirmed that inhalation of sevoflurane alters circadian gene expression, and investigated whether this alteration persists after awakening from… CONTINUE READING

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