Circadian distribution of extra doses of narcotic analgesics in patients with cancer pain: a preliminary report

@article{Bruera1992CircadianDO,
  title={Circadian distribution of extra doses of narcotic analgesics in patients with cancer pain: a preliminary report},
  author={Eduardo Bruera and K Macmillan and Norma Kuehn and Melvin J. Miller},
  journal={Pain},
  year={1992},
  volume={49},
  pages={311-314}
}
In this open study we reviewed the circadian distribution of extra doses of narcotic analgesics in 61 bed-ridden patients with cancer pain. The information was collected prospectively and retrospectively in 34 and 27 cases, respectively. All patients were receiving parenteral narcotics using the Edmonton Injector, and none had incidental pain or cognitive impairment. A total of 1322 extra doses of narcotics (each dose = 10% of the daily dose) were administered during 610 patient days (average… CONTINUE READING

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