Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?

@article{Sephton2003CircadianDI,
  title={Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?},
  author={Sandra E. Sephton and David Spiegel},
  journal={Brain, Behavior, and Immunity},
  year={2003},
  volume={17},
  pages={321-328}
}
Psychosocial factors may modulate the course of cancer, but few data have been gathered on the biological mechanisms by which these effects may be mediated. We briefly review evidence of psychosocial effects on cancer progression and discuss one potential pathway that may underlie these effects: the disruption of neuroendocrine and immune circadian rhythms. Circadian system alterations occur in tumor tissue, tumor-bearing animals, and cancer patients with greater disruption seen in more… CONTINUE READING

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