Circadian dentate gyrus excitability in a rat model of temporal lobe epilepsy

@article{Matzen2012CircadianDG,
  title={Circadian dentate gyrus excitability in a rat model of temporal lobe epilepsy},
  author={Julia Matzen and Katharina Buchheim and Martin Holtkamp},
  journal={Experimental Neurology},
  year={2012},
  volume={234},
  pages={105-111}
}
In human mesial temporal lobe epilepsy (mTLE), seizure occurrence peaks in the late afternoon and early evening. This temporal binding of seizures has been replicated in animal models of mTLE following electrically-induced status epilepticus (SE). We hypothesized that in chronic epilepsy, alterations of circadian excitatory and inhibitory functions of the dentate gyrus (DG), which is believed to regulate the generation of limbic seizures, pathophysiologically contribute to the temporal binding… CONTINUE READING
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