Circadian clocks: regulators of endocrine and metabolic rhythms.

@article{Hastings2007CircadianCR,
  title={Circadian clocks: regulators of endocrine and metabolic rhythms.},
  author={Michael H Hastings and John S. O'Neill and Elizabeth S. Maywood},
  journal={The Journal of endocrinology},
  year={2007},
  volume={195 2},
  pages={187-98}
}
Daily and seasonal rhythms in the endocrine system are co-ordinated by a hypothalamic pacemaker, the suprachiasmatic nuclei (SCN) that is synchronised to solar time by direct retinal afferents. Individual SCN neurons are circadian clocks, their intrinsic oscillator consisting of a series of interlinked autoregulatory transcriptional/post-translational feedback loops incorporating Period (Per) and Cryptochrome (Cry) genes. Mutations that alter the rate of transcription of Per and Cry genes or… CONTINUE READING

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