Circadian clock protein BMAL1 regulates cellular senescence in vivo.

  title={Circadian clock protein BMAL1 regulates cellular senescence in vivo.},
  author={Rohini V. Khapre and Anna A. Kondratova and O. Yu. Susova and Roman V. Kondratov},
  journal={Cell cycle},
  volume={10 23},
Deficiency of the circadian clock transcriptional factor BMAL1 results in the development of premature aging in mice. In agreement with the accelerated aging phenotype, we observed an increase in the number of senescent cells in different tissues (lungs, liver and spleen) of Bmal1(-/-) mice, which suggests the important role of BMAL1 in the control of senescence in vivo. However, no difference in the rate of proliferation and senescence between primary fibroblasts isolated from wild-type and… CONTINUE READING
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