Circadian clock functions localized in xenopus retinal photoreceptors.

@article{Cahill1993CircadianCF,
  title={Circadian clock functions localized in xenopus retinal photoreceptors.},
  author={Gregory M. Cahill and Joseph C. Besharse},
  journal={Neuron},
  year={1993},
  volume={10 4},
  pages={573-7}
}
A circadian oscillator that regulates visual function is located somewhere within the vertebrate eye. To determine whether circadian rhythmicity is generated by retinal photoreceptors, we isolated and cultured photoreceptor layers from Xenopus retina. On average, 94% of the viable cells in these preparations were rod or cone photoreceptors. Photoreceptor layers produced melatonin rhythmically, with an average period of 24.3 hr, in constant darkness. The phase of the melatonin rhythm was reset… CONTINUE READING
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