Circadian clock disruption in neurodegenerative diseases: cause and effect?

  title={Circadian clock disruption in neurodegenerative diseases: cause and effect?},
  author={Erik S Musiek},
  booktitle={Front. Pharmacol.},
Disturbance of the circadian system, manifested as disrupted daily rhythms of physiologic parameters such as sleep, activity, and hormone secretion, has long been observed as a symptom of several neurodegenerative diseases, including Alzheimer disease. Circadian abnormalities have generally been considered consequences of the neurodegeneration. Recent evidence suggests, however, that circadian disruption might actually contribute to the neurodegenerative process, and thus might be a modifiable… CONTINUE READING
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