Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.

@article{Mauvoisin2014CircadianCA,
  title={Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.},
  author={Daniel Mauvoisin and Jingkui Wang and C{\'e}line Jouffe and Eva Mart{\'i}n and Florian Atger and Patrice Waridel and Manfredo Quadroni and Fr{\'e}d{\'e}ric Gachon and Felix Naef},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 1},
  pages={167-72}
}
Diurnal oscillations of gene expression controlled by the circadian clock underlie rhythmic physiology across most living organisms. Although such rhythms have been extensively studied at the level of transcription and mRNA accumulation, little is known about the accumulation patterns of proteins. Here, we quantified temporal profiles in the murine hepatic proteome under physiological light-dark conditions using stable isotope labeling by amino acids quantitative MS. Our analysis identified… CONTINUE READING
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