Circadian changes in pulsatile TSH release in primary hypothyroidism.


OBJECTIVE We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS Nine patients with overt primary hypothyroidism, seven patients with subclinical… (More)


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